Cellular metabolomics is an important reference for assessing phenotypic heterogeneity. When the living environment of a cell population changes drastically, the difference between different cell individuals will be the key to determining cell fate. At present, the theory and application of metabolomics at the single-cell level are gradually improved. Creative Biolabs has established a relatively mature platform for single-cell metabolomics technology, which is expected to achieve more complete metabolome coverage, better and faster identification of metabolites and improvement of nondestructive testing.
Single Metabolomics
In recent years, the potential of single-cell omics in the diagnosis and treatment of diseases has begun to attract attention, and the number of research topics and medical projects related to single-cell genomics, transcriptome, proteomics, and metabolomics has increased significantly. A metabolome is defined as a set of small molecule metabolites found in a particular cell, organ or organism. Due to the highly dynamic nature of cellular metabolism, single-cell metabolomics can be used to discover chemical strategies by which cells respond to chemical or environmental stresses. Compared to other single-cell omics, metabolomics describes cell function more directly and dynamically, but this is undoubtedly the most difficult to measure. This is because the metabolites have a large structural diversity, a wide dynamic range, the inability to amplify metabolites, and the use of fluorescent labels may distort their normal function, allow dynamic response to the environment in a short period of time.
Learn more: Single Metabolomics Platform
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