Although pseudouridylation (Ψ) is one of the most widespread modifications of ribosomal RNA (rRNA), much remains to be understood about the mechanism and impact of this modification. As a leader in ribosome services, Creative Biolabs focuses on providing customers with Ψ related background information and cost-effective ribosome and rRNA analysis services to facilitate the research process of your project.
Introduction to Ψ
RNA modifications play significant roles in many biological processes. They can regulate the fate of RNA molecules, at the cellular and biological levels, such as cell differentiation and sex determination. Ψ, the C-glycoside isomer of uridine, is the most common single-nucleotide modification in functional RNAs, frequently occurring in highly conserved regions of RNAs. Scientists have discovered that many Ψ sites are located at key ribosomal sites, such as tRNA and mRNA binding sites. Ψ is present in almost all species and various types of RNA, including rRNA, transfer RNA (tRNA), small nucleolar RNA (snoRNA), and messenger RNA (mRNA).
Learn more: Pseudouridylation Ψ Machinery
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