Microglia-containing Human Brain Organoids

Microglia stands out as the brain's resident immune cells, tasked with monitoring and safeguarding neural integrity. The study of microglia in their natural habitat has long been a challenge.

The Role of Microglia in the Brain

Microglia, often referred to as the brain's immune cells, play a pivotal role in maintaining the brain's health and functionality. Traditionally, they have been viewed as immune sentinels, responding to infection or injury. However, some research has revealed that microglia's duties encompass far more than just immune defense.

Immune Surveillance. Microglia are constantly monitoring their environment. They can sense disturbances in neural tissue, such as misfolded proteins or damaged cells, and respond swiftly to these threats.

Synaptic Pruning. Microglia are actively involved in synaptic pruning, a process crucial for refining neural connections during development and adapting to new experiences.

Cytokine Regulation. Microglia secrete cytokines and other signaling molecules that influence the surrounding neural environment.

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