In recent decades, cardiovascular diseases were the major causes of morbidity and mortality in the world. As adult cardiomyocytes are terminally differentiated, and they are impossible to further proliferate in application of cell replacement therapy, the most promising cell types for cardiovascular regenerative medicine are human induced pluripotent stem cells (hiPSCs) which have the ability to differentiate into various cell types and proliferate in pluripotent state. The technique for differentiating iPSC into cardiomyocytes involves three stages:
Firstly, the initiation of mesoderm formation
Second, specification of cardiac lineage from mesoderm cells
Lastly, the maturation of cardiac cells
Learn more: ipsc differentiation to cardiomyocytes
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