Immune Checkpoint CTLA-4 for Drug Development

Immune checkpoint molecules, such as CTLA-4, have emerged as a potent weapon in the fight against immune damage in recent years. When treating diseases, the immune response of T cells regulated by checkpoint molecules can prevent unintentional activation. Thus far, CTLA-4 molecules have demonstrated an essential function in controlling the T-cell response to infectious diseases, the self-tolerance of autoimmune diseases, and the antitumor activity of different cancers. According to data from various disease models, antigen-specific tumor elimination in vivo can be achieved through the effective blockade of the CTLA-4 and CD80/CD86 pathway.

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