IgM Production and Purification Service

IgM is the predominant isotype generated early in the initial response to antigens and the first antibody class expressed in the human embryo. Generally speaking, the immune system produces IgMs, which are crucial for both innate and adaptive humoral immune responses. IgM monomeric molecules are made up of two identical heavy chains (μ) and two light chains (κ or λ), much like other kinds of antibody molecules. Pentamer IgM (~950 kDa), which is made up of five monomers joined by the joining-(J) chain, is the most common type seen in human serum. The other forms, such as hexamers (~1100kDa) and monomers (~170kDa), can also be found at rather a low abundance in vivo.

For more information: IgM Production and Purification Service