HD Mouse Models

Mouse models of Huntington's disease (HD) are critical to the development of our understanding of gene expression changes in this disease, and to elucidate the relationship between gene expression and behavior. Creative Biolabs' scientists have extensive experience and excellent skills in the field of neuroscience. Our goal is to provide our customers with affordable development services and reliable results.

About HD

HD is an autosomal dominant neurodegenerative disorder, resulting in expansion of the CAG repeat in exon 1 of the HTT gene. It is a devastating illness that usually strikes between the ages of 35 and 45. The disease is transmitted in an autosomal dominant manner and is caused by an expansion of a CAG repeat region in the gene encoding huntingtin, a protein of unknown function.

Mouse Models of HD

HD mouse models have allowed mutant and wild-type huntingtin (Htt) expression and gene manipulation, the CAG repeat length, the size of protein fragments inserted into the genome, and the effects of stable and induced expression.