HD In Vitro Assay

HDIn VitroAssay

Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by striatal pathology, and its most prominent symptoms include uncontrolled chorea-like movements, mental disorders, progressive dementia, and typical cognitive and emotional deficits. The diagnosis is made based on these manifestations clinically. With the help of the services Creative Biolabs provided, you can explore HD disease in a more convenient, accurate, and thorough way.

Pathology of Huntington’s Disease

HD is inherited in an autosomal dominant manner. In 1993, the International Huntington's Disease Collaborative Research Group cloned the disease-causing gene IT35 and identified this gene as the Huntingtin (HTT) gene. HTT is located in the upper part of chromosome 4 and has a unique characteristic of DNA glutamine trinucleotide repeats. Huntingtin's protein, a metabolite of the HTT gene, is distributed throughout the body, and its function under normal conditions has not yet been fully elucidated.